How to take prepopik®
Instructions
Read the instructions or watch the video

PREPOPIK® offers two dosing options: Split-Dose (preferred method) and Day-Before. Your healthcare provider will determine which one is right for you.

Prepping can remove a lot of fluid from your body. It’s very important to hydrate before, during, and after your procedure to reduce the risk of dehydration and increase the likelihood of a successful procedure.

Medicate:
Packet 1
Night before
(Between 5-9 PM)
Hydrate:
After Packet 1
Drink 5 8-oz (upper line) cups of clear liquid over the next 5 hours
Packet 2
Morning of
(5 hours before)
After Packet 2
Drink at least 3 8-oz cups of clear liquid. You may continue hydrating up to 2 hours before your colonoscopy
For each packet taken separately:
1: Fill

Fill the dosing cup with cold water up to the lower line (5 oz)

2: Pour

Pour in the contents of the packet

3: Stir

Stir for 3 minutes until powder is dissolved

  • Cup may feel warm to the touch as the medication activates
4: Drink it all

Make sure to drink the entire solution

Hydrate using the recommended clear liquids

Drink clear liquids

  • Water
  • Clear broth
  • Apple juice
  • Ginger ale
  • White cranberry juice
  • Plain gelatin (NO red or purple)
  • Frozen juice bars (NO red or purple)
  • White grape juice
Don’t drink

anything you can’t see through

  • NO red or purple liquids
  • NO milk or dairy
  • NO alcohol
Do not eat*

the day before and day of procedure

*Make sure to follow the hydration and dietary instructions given to you by your healthcare provider.

Download the Instructions

Download
Watch Instructional Video
Medicate:
Packet 1
Afternoon before
(Between 4-6 PM)
Hydrate:
After Packet 1
Drink 5 8-oz (upper line) cups of clear liquid over the next 5 hours
Packet 2
Night before
(Between 10 PM-12 AM)
After Packet 2
Drink 3 8-oz cups of clear liquid or more, as recommended by your doctor. You may continue hydrating up to 2 hours before your colonoscopy
For each packet taken separately:
1: Fill

Fill the dosing cup with cold water up to the lower line (5 oz)

2: Pour

Pour in the contents of the packet

3: Stir

Stir for 3 minutes until powder is dissolved

  • Cup may feel warm to the touch as the medication activates
4: Drink it all

Make sure to drink the entire solution

Hydrate using the recommended clear liquids

Drink clear liquids

  • Water
  • Clear broth
  • Apple juice
  • Ginger ale
  • White cranberry juice
  • Plain gelatin (NO red or purple)
  • Frozen juice bars (NO red or purple)
  • White grape juice
Don’t drink

anything you can’t see through

  • NO red or purple liquids
  • NO milk or dairy
  • NO alcohol
Do not eat*

the day before and day of procedure

*Make sure to follow the hydration and dietary instructions given to you by your healthcare provider.

Download the Instructions

Download
Watch Instructional Video
PREPOPIK® Dosing Tool
A 2-step tool to help you determine your dosing schedule
1
First

Select the dosing regimen prescribed by your healthcare provider*

*Always follow the directions set by your healthcare provider.
2
Next

Enter the time of
your scheduled appointment:

Your Dosing Schedule

Start your 1st dose at:

00:00 xm

Drink 40 oz of the recommended clear liquids by 00:00 xm.

Start your 2nd dose at:

00:00 xm

Drink 24 oz of the recommended clear liquids by 00:00 xm.

Colonoscopy Checklist
Your healthcare team will tend to you during your colonoscopy. Here are some tips and things to think about before and after your colonoscopy:
Prep for the prep
Start hydrating
  • Start hydrating before you start the prep, and follow your healthcare provider’s instructions
Get ready for your big day
  • Schedule the day off from work and arrange for a friend or family member to take you to and from your procedure
  • Fill your colonoscopy prep prescription
Download tools to help you prep
  • Download the Patient Prep Kit or the Colonoscopy Checklist to stay reminded of important instructions
  • Call your healthcare provider if you have any questions
    • Remember to talk to your healthcare provider about any medications you are taking
Prep day
It’s time to prep
  • Make sure to refer to dosing instructions and recommended clear liquids in How to Take PREPOPIK®
  • Remember, each dose of PREPOPIK® must be stirred for 3 minutes!
  • Wear pants that are easy to take off and on repeatedly and stay near a bathroom—you’ll be spending a lot of time in there
Don’t forget the essentials
  • Stock up on toilet paper, wet wipes, and clear liquids
  • Download movies, TV shows, books, games, and apps to keep you entertained while you prep
After your colonoscopy
Time to unwind
  • Plan on resting the remainder of the day, and don’t drive or operate any machinery
  • Ease back into eating—you might feel very hungry, but start with a light meal and gradually return to your normal diet
  • Motivate more people to get a colonoscopy and protect themselves from colorectal cancer. In fact, you can Tell a Friend about PREPOPIK®!

Download the Checklist

Download
  • In a clinical trial, 96% of patients said they would take Split Dose PREPOPIK® again and 89% found it very easy or easy to take vs 55% and 29%, respectively, for a Day-Before comparator (2L PEG+E plus 2 x 5 mg bisacodyl tablets)
  • PREPOPIK® has been found effective as a bowel prep in both Split-Dose and Day-Before dosing regimens. Learn more

Indication and Important Safety Information

PREPOPIK® is a prescription medicine used by adults to clean the colon before a colonoscopy. PREPOPIK® cleans your colon by causing you to have diarrhea. Cleaning your colon helps your healthcare provider see the inside of your colon more clearly during your colonoscopy.

  • Do not take PREPOPIK® if your healthcare provider has told you that you have serious kidney problems, a blockage in your intestine (bowel obstruction), an opening in the wall of your stomach or intestines (bowel perforation), a very dilated intestine (toxic megacolon), problems with the emptying of food and fluid from your stomach (gastric retention), or an allergy to any of the ingredients in PREPOPIK®
  • Tell your healthcare provider right away if you have any of these symptoms of a loss of too much body fluid (dehydration) while taking PREPOPIK®: vomiting that prevents you from keeping down the additional prescribed amounts of clear liquids that you must drink after taking PREPOPIK®, dizziness, urinating less often than normal, or headache
  • PREPOPIK® and other bowel preparations can cause serious side effects, including serious loss of body fluid (dehydration) and changes in blood salts (electrolytes) in your blood. These changes can cause abnormal heartbeats that can cause death, seizures (this can happen even if you have never had a seizure), or kidney problems. Your chance of having fluid loss and changes in blood salts with PREPOPIK® is higher if you have heart problems, have kidney problems, or take water pills or non-steroidal anti-inflammatory drugs (NSAIDS)
  • The most common side effects of PREPOPIK® include nausea, headache, and vomiting. These are not all the possible side effects of PREPOPIK®

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.